IntroductionThe ubiquitin-proteasome system (UPS) is an intracellular organelle responsible for targeted protein degradation, which represents a standard therapeutic target for many different human malignancies.Bortezomib, a reversible inhibitor of chymotrypsin-like proteasome activity, was first approved by the FDA in 2003 to treat multiple myelom
The use of LED lights in smart street lighting to save Freezer Door Handle Base energy is efficient and very common in many developed cities.However, such a system results in higher initial costs, which may discourage smaller towns and villages from its purchasing.This paper therefore deals with the design and development of a smart street lighting
IntroductionDesert ecosystems harbor a unique microbial diversity that is crucial for ecological stability and biogeochemical cycles.An in-depth understanding of the biodiversity, compositions, and functions of these microbial communities is imperative to navigate global changes and confront potential threats and opportunities applicable to agricul
The development of broad-spectrum antivirals against human coronaviruses (HCoVs) is critical to combat the current coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants, as well as future outbreaks of emerging Moka Pot CoVs.We have previously identified a polyethylene gl